Amalungiselelo kufuneka "ukuxuba" imathiriyeli ekrwada kwezinye ii-excipients okanye izinyibilikisi ukufikelela kugxininiso olufunekayo, kwaye ekugqibeleni lunokunikezelwa kwithagethi yechiza ukuze isetyenziswe.Iindlela ezahlukeneyo zamalungiselelo zixazulula ingxaki yokusetyenziswa kweziyobisi kunye nethamo, kodwa zikwabeka phambili iimfuno eziphezulu zokhuseleko.Ukuze kugcinwe iyunifomu yemveliso kwaye izinzile, izithako ezisebenzayo zihlangabezana neemfuno zokusetyenziswa kweziyobisi, kunye nokulawula ubungozi obunokubakho, inkqubo kufuneka ixhotyiswe ngezisombululo ezichanekileyo zokucoca ukuqinisekisa ukuthotyelwa kwemveliso kunye nokhuseleko, ngokuhambelana neemfuno ze-GMP.
Ukusetyenziswa kweteknoloji yamachiza yanamhlanje, ichiza liya kusasazwa kwisakhiwo esikhethekileyo senkqubo, ukwenzela ukuba utshintshe iimpawu ze-pharmacokinetic kunye nokusabalalisa izicubu zeyeza emzimbeni, ukuphucula ukusebenza kwesiphumo.Oku kufuna ubungakanani obufanayo bokuvuleka kwesihluzi, isakhono esinamandla sokucanda, akukho kuvuza kwamasuntswana;Akukho mfuduko wemidiya, ayichaphazeli i-PH yoshishino lwamayeza;I-adsorption encinci, isantya sokuhluza ngokukhawuleza, ayichaphazeli umxholo weyeza eliphambili.