Kukhulupirika ndiye vuto lalikulu pakupanga ndi kugwiritsa ntchito zinthu zosefera.Muzinthu zambiri zamadzimadzi (gasi kapena zamadzimadzi) zothira mafuta, kukhulupirika kwakukulu kwa fyuluta kumafunika pomaliza kupanga komanso pambuyo pogwiritsidwa ntchito kwenikweni.Chifukwa chake, zosefera zazakudya ndi mankhwala ziyenera kukhala ndi kukhulupirika kotheratu kwa mayeso, zolemba zoyeserera ndi zolemba
Integtest series integrity tester ndi chida chapadera choyesera kukhulupirika kwa zinthu zosefera ndi makina osewerera, zomwe zimakwaniritsa zofunikira za FDA, National Pharmacopoeia ndi GMP potsimikizira zosefera za bactericidal.